Musacchia X J
Cryobiology. 1984 Dec;21(6):583-92. doi: 10.1016/0011-2240(84)90219-0.
It is obvious that research is far from the last chapter in developing a model for natural hibernation. The relationships and comparative mechanisms for thermogenesis and survival in hibernation and experimental hypothermia are still unclear. Yet, two primary areas appear to be most promising, namely, the control of thermogenesis via the glucocorticoids and the specific role of the central nervous system (CNS) in survival of hypothermic subjects and arousal of hibernating subjects. Although there have been several approaches to understanding the role of the CNS in terms of circulation, integrity of the blood-brain barrier (BBB) system, and CNS sites of activity, it may appear that more questions have been raised than have been answered. However, a more optimistic view can also be taken. The development of a laboratory model, using experimental hypothermia for natural hibernation, is progressing. This view is justified in terms of results from the use of glucocorticoids in metabolic regulation of available carbohydrates, i.e., available glucose in hypothermia, and the continued promising parallel studies of physiological and biochemical integrity of areas of the CNS in hypothermic and hibernating subjects.
显然，在建立自然冬眠模型的研究远未结束。冬眠和实验性低温状态下产热与生存的关系及比较机制仍不清楚。然而，有两个主要领域似乎最具前景，即通过糖皮质激素控制产热以及中枢神经系统（CNS）在低温受试者生存和冬眠动物觉醒中的特定作用。尽管已经有几种方法从循环、血脑屏障（BBB）系统的完整性以及CNS的活动位点来理解CNS的作用，但似乎提出的问题比得到解答的更多。然而，也可以持更乐观的观点。利用实验性低温模拟自然冬眠的实验室模型正在不断发展。从糖皮质激素在调节可用碳水化合物（即低温状态下的可用葡萄糖）代谢中的应用结果来看，以及对低温和冬眠动物CNS区域生理和生化完整性的持续有前景的平行研究来看，这种观点是合理的。
