Krause W, Kampf D, Fischer H C
Eur J Clin Pharmacol. 1984;27(4):429-33. doi: 10.1007/BF00549590.
Five patients with a creatinine clearance of 14 to 37 ml/min/1.73 m2 were each given an oral dose of 10 mg of the beta-blocker mepindolol sulphate (Corindolan). In addition, two dialysis patients received the same dose either during hemodialysis or on a dialysis-free day. Plasma levels of mepindolol were measured by a sensitive, specific HPLC method. Mepindolol was rapidly absorbed in all the patients. The maximum plasma level of 35 +/- 8 ng/ml was reached after 1.4 +/- 0.5 h. The half-life of disposition was 4.0 +/- 1.5 h. The area under the plasma concentration-time curve was 237 +/- 84 ng X h/ml. The data obtained were no different from those found in normal healthy volunteers.
五名肌酐清除率为14至37毫升/分钟/1.73平方米的患者分别口服了10毫克β受体阻滞剂硫酸美品洛尔（Corindolan）。此外，两名透析患者在血液透析期间或非透析日接受了相同剂量。采用灵敏、特异的高效液相色谱法测定美品洛尔的血浆水平。美品洛尔在所有患者中均迅速吸收。1.4±0.5小时后达到最大血浆水平35±8纳克/毫升。处置半衰期为4.0±1.5小时。血浆浓度-时间曲线下面积为237±84纳克·小时/毫升。获得的数据与正常健康志愿者的数据无差异。
