Krause W
J Chromatogr. 1980 Jan 11;181(1):67-75. doi: 10.1016/s0378-4347(00)81270-0.
A method for determining the plasma concentration of the beta-receptor blocking agent mepindolol by high-performance liquid column chromatography (paired-ion chromatography) and electrochemical detection is described. Pindolol is used as an internal standard and the detection limit after extraction of 1 ml of plasma is less than 1 ng of mepindolol. Reproducible results can be obtained with relative standard deviations from replicate analyses of 5 ng/ml plasma samples within +/- 4.7%. The method is also suitable for quantification of plasma pindolol levels with mepindolol as an internal standard.
描述了一种通过高效液相柱色谱法（离子对色谱法）和电化学检测来测定β受体阻滞剂美吡咯醇血浆浓度的方法。吲哚洛尔用作内标，提取1ml血浆后的检测限低于1ng美吡咯醇。对5ng/ml血浆样品进行重复分析，相对标准偏差在±4.7%以内，可获得可重现的结果。该方法也适用于以美吡咯醇为内标定量血浆中吲哚洛尔的水平。
