Baer P G
Hypertension. 1984 Nov-Dec;6(6 Pt 1):861-7. doi: 10.1161/01.hyp.6.6.861.
The relationship of blood pressure (BP) to vascular hyperresponsiveness to norepinephrine (NE) in New Zealand genetically hypertensive (NZGH) rats was studied with an isolated, perfused hindquarters preparation. Four separate studies were conducted, and the findings were as follows. 1) Compared with New Zealand normotensive rats (NZNR), NZGH rats by 3 weeks of age clearly showed hyperresponsiveness, although the BP difference had not yet fully developed. 2) Bilateral renal denervation of NZGH at 3 weeks of age delayed the development of hypertension for 4 weeks, but did not lessen the vascular hyperresponsiveness. 3) In one-kidney, one clip renal hypertensive NZNR, vascular responsiveness was increased but remained less than that of age-matched NZGH. 4) In an F2 generation of NZGH-NZNR cross-bred rats, the average adult systolic BP was 163 mm Hg, similar to that of the NZGH parent strain; however, vascular responsiveness was reduced to an intermediate level, lower than that of NZGH but higher than that of NZNR. It is concluded that the vascular hyperresponsiveness of NZGH rats to NE is a primary characteristic that can be largely dissociated from elevated BP.
利用离体灌注后肢标本，研究了新西兰遗传性高血压（NZGH）大鼠的血压（BP）与血管对去甲肾上腺素（NE）的高反应性之间的关系。进行了四项独立研究，结果如下。1）与新西兰正常血压大鼠（NZNR）相比，3周龄的NZGH大鼠虽然血压差异尚未完全显现，但已明显表现出高反应性。2）3周龄时对NZGH大鼠进行双侧肾去神经支配可使高血压的发展延迟4周，但并未减轻血管高反应性。3）在单肾单夹肾性高血压的NZNR大鼠中，血管反应性增加，但仍低于年龄匹配的NZGH大鼠。4）在NZGH-NZNR杂交大鼠的F2代中，成年大鼠的平均收缩压为163 mmHg，与NZGH亲本品系相似；然而，血管反应性降低到中等水平，低于NZGH大鼠但高于NZNR大鼠。结论是，NZGH大鼠对NE的血管高反应性是一个主要特征，在很大程度上可与血压升高相分离。
