Kishima M, Hashimoto K, Minato H
Natl Inst Anim Health Q (Tokyo). 1978 Spring;18(1):18-26.
A total of 155 Mycoplasma strains were examined for sensitivity to nine antibiotics and four nitrofurans by the agar dilution method. They consisted of 69 strains of Mycoplasma bovirhinis, 33 strains of M. bovigenitalium, 49 strains of Acholeplasma laidlawii and four strains of A. modicum isolated from the nasal secretions, tracheas and lungs of calves manifesting respiratory symptoms and from bovine genital tracts collected at a slaughterhouse. As a result, furamizole and mitomycin C showed the strongest growth-inhibiting effect on all the strains. They were followed in this effect by kitasamycin tartrate, spiramycin adipate, tylosin tartrate, tetracycline-HCl and chloramphenicol. Furthermore, these five drugs were followed in the effect by furazolidone, nitrofurantoin and sodium nifurstyrenate. Fradiomycin sulfate and kanamycin sulfate showed only little effect on all the strains. Erythromycin lactobionate showed a strong growth-inhibiting effect on the Acholeplasma strains, but not on the Mycoplasma strains. There were some cross resistant strains of the Acholeplasma species to the effects of the macrolides.
采用琼脂稀释法对155株支原体菌株进行了9种抗生素和4种硝基呋喃类药物的敏感性检测。这些菌株包括从表现出呼吸道症状的犊牛的鼻分泌物、气管和肺以及从屠宰场采集的牛生殖道中分离出的69株牛鼻支原体、33株牛生殖支原体、49株莱氏无胆甾原体和4株少量无胆甾原体。结果，呋喃咪唑和丝裂霉素C对所有菌株均表现出最强的生长抑制作用。其次是酒石酸吉他霉素、己二酸螺旋霉素、酒石酸泰乐菌素、盐酸四环素和氯霉素。此外，这五种药物之后依次是呋喃唑酮、呋喃妥因和硝呋甾烯腙。硫酸新霉素和硫酸卡那霉素对所有菌株的作用很小。乳糖酸红霉素对无胆甾原体菌株表现出较强的生长抑制作用，但对支原体菌株无此作用。无胆甾原体属的一些菌株对大环内酯类药物的作用存在交叉耐药性。
