Liberman U
J Math Biol. 1984;21(1):1-10. doi: 10.1007/BF00275218.
The count-location (C-L) chiasma formation schemes introduced by Karlin and Liberman (1979b) encompass a broad class of map functions involving positive, negative or no chiasma interference. The C-L schemes do not explicitly assume a specific mechanism of crossover formation, but rather a statistical property of the process. If viewed as a stochastic point process along the chromosome, it is shown that a crossing over mechanism having the C-L property is actually a rescaled mixture of Poisson processes. Surprisingly it turns out that these C-L point processes involve negative interference throughout the entire genome.
卡林和利伯曼(1979b)提出的计数-定位(C-L)交叉形成方案涵盖了一大类涉及正、负或无交叉干扰的图谱函数。C-L方案并未明确假定特定的交叉形成机制,而是假定该过程的一种统计特性。如果将其视为沿染色体的随机点过程,可以证明具有C-L特性的交叉机制实际上是泊松过程的重标混合。令人惊讶的是,结果表明这些C-L点过程在整个基因组中都涉及负干扰。