Lieb J, Balter A
Med Hypotheses. 1984 Nov;15(3):279-91. doi: 10.1016/0306-9877(84)90018-5.
We report eleven patients in whom tachyphylaxis to antidepressants, lithium or ECT occurred. These cases are a small sample of patients we have encountered in whom an initial good response to mood regulating drugs was not sustained. We suspect that systematic studies would reveal that tachyphylaxis is a common phenomenon with antidepressant therapies.
我们报告了11例对抗抑郁药、锂盐或电休克治疗(ECT)出现快速耐受的患者。这些病例只是我们所遇到的一小部分患者,他们最初对情绪调节药物有良好反应,但这种反应并未持续。我们怀疑系统性研究将揭示快速耐受是抗抑郁治疗中的常见现象。