Takeda T, Ikeda K
Nucleic Acids Symp Ser. 1984(15):101-4.
Dodecathymidylic acids containing alpha-putrescinylthymidine, 5-methylamino-methyl-2'-deoxyuridine and 5-methoxymethyl-2'-deoxyuridine were prepared by the phosphotriester polymer support synthesis. The melting temperatures of the synthetic oligomers-polydeoxyadenylic acid complexes show that the secondary amino group at putrescinylthymidine decreases the thermal stability of complexes and the primary amino group at the putrescinyl residue increases the stability.
通过磷酸三酯聚合物载体合成法制备了含有α-腐胺基胸苷、5-甲基氨基甲基-2'-脱氧尿苷和5-甲氧基甲基-2'-脱氧尿苷的十二聚胸苷酸。合成的低聚物-聚脱氧腺苷酸复合物的熔解温度表明，腐胺基胸苷上的仲氨基降低了复合物的热稳定性，而腐胺残基上的伯氨基则增加了稳定性。
