Pasinetti G, Govoni S, Battaini F, Locatelli P, Faccini E, Trabucchi M
Pharmacol Res Commun. 1984 Dec;16(12):1175-82. doi: 10.1016/s0031-6989(84)80082-x.
Immunocytochemical and electrophysiological studies indicate the existence of a functional relationship between Cholecystokinin (CCK) and dopaminergic transmission. In order to gain more information on this relationship, the effect of Caerulein, a CCK stable analogue, on rat spontaneous locomotor activity and on biochemical markers of dopaminergic transmission were measured simultaneously. The concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and the spontaneous or K+ evoked release of dopamine were studied in rat striatum and nucleus accumbens immediately after testing for motor activity. An almost complete reduction in locomotor activity but not significant changes in DOPAC content and dopamine release were observed in rats injected with the peptide (0.25/microgram/Kg, intraperitoneally). DOPAC concentrations were slightly (30%) decreased by increasing 200 folds caerulein dose. In addition, a very minute dose of haloperidol (25 /microgram/Kg) potentiated the caerulein (0.25/microgram/Kg) induced hypomotility, while the parameters of dopaminergic metabolism were unaffected. Our results indicate the existence of a relevant pharmacological interaction between caerulein and dopamine antagonists, although it is not clear whether this interaction takes place at the dopamine terminals level.
免疫细胞化学和电生理研究表明胆囊收缩素（CCK）与多巴胺能传递之间存在功能关系。为了获取更多关于这种关系的信息，我们同时测量了CCK稳定类似物蛙皮素对大鼠自发运动活性以及多巴胺能传递生化标志物的影响。在对运动活性进行测试后，立即研究大鼠纹状体和伏隔核中3,4-二羟基苯乙酸（DOPAC）的浓度以及多巴胺的自发释放或K +诱导释放。在腹腔注射该肽（0.25微克/千克）的大鼠中，观察到运动活性几乎完全降低，但DOPAC含量和多巴胺释放没有显著变化。将蛙皮素剂量增加200倍会使DOPAC浓度略有降低（30%）。此外，极微量的氟哌啶醇（25微克/千克）会增强蛙皮素（0.25微克/千克）诱导的运动减退，而多巴胺能代谢参数未受影响。我们的结果表明蛙皮素与多巴胺拮抗剂之间存在相关的药理相互作用，尽管尚不清楚这种相互作用是否发生在多巴胺终末水平。
