Hamilton M, Sheehan M J, De Belleroche J, Herberg L J
Neurosci Lett. 1984 Jan 27;44(1):77-82. doi: 10.1016/0304-3940(84)90224-6.
We have investigated the effect of the cholecystokinin (CCK) analogue, caerulein, in the nucleus accumbens on dopamine (DA) release and locomotor activity. Caerulein (10(-9)-10(-4) M) did not affect the resting or K+-evoked release of [14C]DA, although concentrations within this range have been shown to modulate transmitter release in cerebral cortex. When injected bilaterally into the nucleus accumbens, caerulein (30 ng-1 microgram) did not affect spontaneous locomotor activity as compared to vehicle-injected controls. Similarly, bilateral injections of caerulein (1 microgram) into the nucleus accumbens did not modulate locomotor hyperactivity induced by bilateral injections of DA (20 microgram) into the nucleus accumbens. It is concluded that CCK in the nucleus accumbens has no direct effect on dopamine release or dopamine-stimulated locomotor activity.
我们研究了胆囊收缩素（CCK）类似物蛙皮素对伏隔核中多巴胺（DA）释放及运动活性的影响。尽管已表明该浓度范围内的蛙皮素（10⁻⁹ - 10⁻⁴ M）可调节大脑皮层中的递质释放，但它并不影响[¹⁴C]DA的静息释放或K⁺诱发释放。与注射赋形剂的对照组相比，双侧注射到伏隔核中的蛙皮素（30 ng - 1 μg）不影响自发运动活性。同样，双侧向伏隔核注射蛙皮素（1 μg）也不会调节双侧向伏隔核注射DA（20 μg）所诱导的运动亢进。结论是伏隔核中的CCK对多巴胺释放或多巴胺刺激的运动活性没有直接影响。
