Ali B H, Khogali A
Res Vet Sci. 1984 Nov;37(3):290-2.
Chickens were treated orally with furazolidone at dose rates of 40 or 80 mg kg-1 for five days or fed the drug at concentrations of 0.04 per cent w/w or 0.08 per cent w/w for 10 days. Plasma constituents, liver, heart, kidney, cerebrum, cerebellum and testes were examined. Furazolidone at the recommended therapeutic dose rate of 0.04 per cent w/w for 10 days or at a dose rate of 40 mg kg-1 for five days produced no significant changes in morphology or plasma parameters measured. At a dose rate of 0.08 per cent w/w for 10 days or 80 mg kg-1 for five days, furazolidone produced significant decreases in the concentrations of total protein and cholesterol and tended to increase the activity of cholinesterase. In the plasma, concentrations of potassium increased and concentrations of sodium decreased. Histologically, congestion and some degenerative changes were observed in the tissues examined.
以40或80毫克/千克的剂量率给鸡口服呋喃唑酮，持续五天，或以0.04%（重量/重量）或0.08%（重量/重量）的浓度投喂该药物，持续十天。对血浆成分、肝脏、心脏、肾脏、大脑、小脑和睾丸进行了检查。以0.04%（重量/重量）的推荐治疗剂量率投喂十天或以40毫克/千克的剂量率投喂五天的呋喃唑酮，在所测量的形态学或血浆参数方面未产生显著变化。以0.08%（重量/重量）的剂量率投喂十天或80毫克/千克的剂量率投喂五天时，呋喃唑酮使总蛋白和胆固醇浓度显著降低，并倾向于增加胆碱酯酶的活性。在血浆中，钾浓度升高而钠浓度降低。组织学检查发现，在所检查的组织中出现了充血和一些退行性变化。
