Saito I
Sex Transm Dis. 1984 Oct-Dec;11(4 Suppl):460-2. doi: 10.1097/00007435-198410001-00042.
The effect of thiamphenicol on nongonococcal urethritis was compared with that of doxycycline for 122 male patients, 61 of whom were randomly assigned to treatment with thiamphenicol and 61, with doxycycline. Before treatment the urethral discharges showed more than ten polymorphonuclear leukocytes per high-power field, no gram-negative cocci on the smear, and no culture positive for Neisseria gonorrhoeae. Thiamphenicol was given orally in 500-mg doses three times daily (total dose, 1,500 mg per day), and doxycycline was given orally in 100-mg doses three times daily (total dose, 300 mg per day) for seven to 14 days. Thiamphenicol was clinically effective for 86.8% of the men and doxycycline for 86.3%. In the culture-negative group, thiamphenicol was effective in 90% and doxycycline in 92%; there was no statistically significant difference between the two drugs. Of the 122 patients, one (1.6%) in the doxycycline-treated group showed digestive tract disturbance, but this reaction did not require stopping the therapy.
将122例男性患者的甲砜霉素与强力霉素治疗非淋菌性尿道炎的效果进行了比较，其中61例随机分配接受甲砜霉素治疗，61例接受强力霉素治疗。治疗前，尿道分泌物在高倍视野下显示多形核白细胞超过10个，涂片未见革兰氏阴性球菌，淋病奈瑟菌培养阴性。甲砜霉素口服剂量为500毫克，每日3次（总剂量为每日1500毫克），强力霉素口服剂量为100毫克，每日3次（总剂量为每日300毫克），疗程7至14天。甲砜霉素对86.8%的男性临床有效，强力霉素对86.3%的男性临床有效。在培养阴性组中，甲砜霉素的有效率为90%，强力霉素为92%；两种药物之间无统计学显著差异。在122例患者中，强力霉素治疗组有1例（1.6%）出现消化道紊乱，但这种反应无需停药。
