Boslego J W, Hicks C B, Greenup R, Thomas R J, Wiener H A, Ciak J, Tramont E C
Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D.C.
Sex Transm Dis. 1988 Oct-Dec;15(4):186-91. doi: 10.1097/00007435-198810000-00002.
One hundred fourteen men with uncomplicated urethritis were randomized to receive 1 week of therapy with either doxycycline (100 mg twice daily) or ofloxacin (300 mg twice daily). Of the 109 men completing the post-treatment visit, 56 received ofloxacin and 52 (93%) were clinically cured. Forty four (83%) of the 53 men treated with doxycycline were cured. All 30 patients with gonorrhea (including three with penicillinase-producing Neisseria gonorrhoeae [PPNG] isolates) who were treated with ofloxacin became culture-negative, as compared with 32 of 34 patients receiving doxycycline. In contrast, three of 18 patients with Chlamydia trachomatis were microbiologic failures after ofloxacin therapy, while all ten treated with doxycycline were cured. Adverse effects of both treatment regimens were generally mild, and compliance was excellent except for one patient receiving doxycycline. These results show that ofloxacin, in a dosage of 300 mg taken orally twice daily for seven days, is an effective treatment for uncomplicated urethritis in men but may not reliably cure chlamydial infections.
114例单纯性尿道炎男性患者被随机分为两组，分别接受为期1周的多西环素（100mg，每日2次）或氧氟沙星（300mg，每日2次）治疗。在完成治疗后随访的109例男性患者中，56例接受了氧氟沙星治疗，其中52例（93%）临床治愈。接受多西环素治疗的53例男性患者中有44例（83%）治愈。所有30例接受氧氟沙星治疗的淋病患者（包括3例产青霉素酶淋病奈瑟菌[PPNG]分离株感染患者）培养均转阴，而接受多西环素治疗的34例患者中有32例转阴。相比之下，18例沙眼衣原体感染患者中，有3例在接受氧氟沙星治疗后微生物学治疗失败，而接受多西环素治疗的10例患者均治愈。两种治疗方案的不良反应一般较轻，除1例接受多西环素治疗的患者外，依从性均良好。这些结果表明，氧氟沙星以300mg口服，每日2次，连用7天的剂量，是治疗男性单纯性尿道炎的有效方法，但可能无法可靠地治愈衣原体感染。
