Lewis R J, Endean R
Toxicon. 1984;22(5):805-10. doi: 10.1016/0041-0101(84)90163-6.
Five of six barracuda, Sphyraena jello, captured in the same area of Queensland as toxic Spanish mackerel (Scomberomorus commersoni) were found to be toxic. One major lipid-soluble toxin, present in both the flesh and viscera of a pooled sample of barracuda, was chromatographically indistinguishable from Spanish mackerel flesh ciguatoxin. Signs and symptoms induced by toxic barracuda in humans were typical of ciguatera and cats and mice displayed signs indistinguishable from those induced by Spanish mackerel ciguatoxin. Purified barracuda ciguatoxin had an i.p. LD50 to mice of 55 micrograms/kg. Barracuda ciguatoxin had a narrow range (0.7-1.4 mouse units) of doses between 0% and 100% lethality and its dose vs. death-time relationship was similar to the relationship produced by moray eel and Spanish mackerel ciguatoxin. No water-soluble toxins were detected in the viscera of these barracuda, but a less polar lipid-soluble toxin was found in the viscera. This minor toxin represented 14% of the total viscera lethality and induced signs in mice similar to the major toxin. Barracuda could be an important link in the transfer of ciguatoxin to large Spanish mackerel in southern Queensland waters.
在昆士兰州与有毒的康氏马鲛（Scomberomorus commersoni）相同区域捕获的6条尖吻鲈（Sphyraena jello）中，有5条被发现有毒。在尖吻鲈混合样本的鱼肉和内脏中存在的一种主要脂溶性毒素，经色谱分析与康氏马鲛鱼肉雪卡毒素无法区分。有毒尖吻鲈在人类身上引发的体征和症状是典型的雪卡中毒症状，猫和小鼠表现出的体征与康氏马鲛雪卡毒素引发的体征无法区分。纯化后的尖吻鲈雪卡毒素对小鼠的腹腔注射半数致死量为55微克/千克。尖吻鲈雪卡毒素在0%至100%致死率之间的剂量范围很窄（0.7 - 1.4小鼠单位），其剂量与死亡时间的关系与海鳝和康氏马鲛雪卡毒素产生的关系相似。在这些尖吻鲈的内脏中未检测到水溶性毒素，但在内脏中发现了一种极性较小的脂溶性毒素。这种次要毒素占内脏总致死率的14%，在小鼠身上引发的体征与主要毒素相似。在昆士兰州南部水域，尖吻鲈可能是雪卡毒素向大型康氏马鲛转移的重要环节。
