Tenenbein M
Vet Hum Toxicol. 1984;26 Suppl 2:3-5.
This report describes nine episodes of presumed allergic reactions occurring in seven patients who were treated for acetaminophen overdose with intravenous N-acetylcysteine. All of these reactions were confined to the skin and consisted of urticaria and/or angioedema. All patients were pruritic. There was no evidence of bronchospasm or hypotension. In four of these episodes the intravenous protocol was completed after the parenteral administration of an antihistamine. In all four of these instances there was no progression of the hypersensitivity-like symptoms or signs. Previous case reports of acute allergic reactions to intravenous N-acetylcysteine will be reviewed. The advantages and disadvantages of oral vs. intravenous N-acetylcysteine therapy for acetaminophen overdose will be discussed in light of the hypersensitivity-like reactions to intravenous N-acetylcysteine.
本报告描述了7例对乙酰氨基酚过量患者接受静脉注射N-乙酰半胱氨酸治疗时发生的9次疑似过敏反应。所有这些反应均局限于皮肤，表现为荨麻疹和/或血管性水肿。所有患者均有瘙痒症状。无支气管痉挛或低血压的证据。在其中4次发作中，在胃肠外给予抗组胺药后完成了静脉用药方案。在所有这4例中，类似过敏症状或体征均未进展。将回顾既往关于静脉注射N-乙酰半胱氨酸急性过敏反应的病例报告。鉴于对静脉注射N-乙酰半胱氨酸的类似过敏反应，将讨论口服与静脉注射N-乙酰半胱氨酸治疗对乙酰氨基酚过量的利弊。
