Poulter J M, White W F, Dickerson J W
Acta Vitaminol Enzymol. 1984;6(3):175-82.
The effect of long term ascorbic acid (AA) supplementation (3g per day) on 27 women with early breast cancer has been investigated. For comparison a similar but limited study was carried out in patients with benign breast disease. The responses of leucocyte levels of AA to supplementation provided some evidence to suggest that the metabolism and utilisation of the vitamin may be different in these patients. In addition longitudinal measurements of urinary hydroxyproline/creatinine (OHPro/Cr) ratio were carried out in these patients. The long term ingestion of AA did not appear to affect the prognosis of the disease in the early breast cancer group. Similar 5 year survival rates were seen in the unsupplemented and supplemented cancer groups.
研究了长期补充抗坏血酸（AA）（每天3克）对27例早期乳腺癌女性患者的影响。为作比较，对患有良性乳腺疾病的患者进行了一项类似但规模有限的研究。补充AA后白细胞中AA水平的反应提供了一些证据，表明这些患者体内维生素的代谢和利用可能有所不同。此外，还对这些患者进行了尿羟脯氨酸/肌酐（OHPro/Cr）比值的纵向测量。长期摄入AA似乎并未影响早期乳腺癌组患者的疾病预后。未补充和补充了AA的癌症组的5年生存率相似。
