Longoni P, Cascone G, Imbriani M, Prestinoni A, Ghittori S, Gamba G
Boll Soc Ital Biol Sper. 1984 Nov 30;60(11):2199-205.
The effect of Dimethylformamide on platelet function and on clotting system has been studied on eight workers exposed to the product, widely used in industry as a solvent of acrylic resins. A significant reduction of the number of the platelets and a drawing out of PTT and PT has been noticed. Such informations has been explained as chronical peripheral use or as modification of phospholipid components induced by DMF instead of synthesis defect, as no significant variation of the fibrinogen and of AT III values, proteins synthetized by liver, has been observed. The platelet aggregation has pointed out, in vivo, a reduction of ADP aggregation in the exposed subjects; in vitro, increasing quantities have determined an increasing reduction of the primary ADP and adrenaline aggregation.
已对八名接触二甲基甲酰胺的工人进行了研究，该产品作为丙烯酸树脂的溶剂在工业中广泛使用，研究其对血小板功能和凝血系统的影响。已注意到血小板数量显著减少以及部分凝血活酶时间（PTT）和凝血酶原时间（PT）延长。这些信息被解释为长期外周使用或由二甲基甲酰胺引起的磷脂成分改变，而非合成缺陷，因为未观察到纤维蛋白原和由肝脏合成的抗凝血酶III（AT III）值有显著变化。血小板聚集在体内显示，接触该物质的受试者中ADP诱导的聚集减少；在体外，二甲基甲酰胺量的增加导致初级ADP和肾上腺素诱导的聚集减少程度增加。
