[一种采用氮磷检测器的微分析气液色谱法用于测定各种三环结构精神药物及其N-去甲基代谢产物]
[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].
作者信息
Sgaragli G P, Della Corte L, Giovannini M G, Ninci R, Franco C, Nardini M
出版信息
Boll Soc Ital Biol Sper. 1984 Sep 30;60(9):1757-63.
PMID:6525296
Abstract
Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with significant time and materials saving, as compared to the use of organic solvents in a three steps extraction procedure.
摘要
采用带氮敏检测的气相色谱法在血浆中检测到纳克量的氯米帕明、氯丙嗪及其N-1和N-2代谢物。比较了两种提取方法。与三步有机溶剂提取法相比，使用Sep Pak C18柱提取具有更高的准确度和精密度，且显著节省时间和材料。
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