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[血浆中氯米帕明及其NOR1和NOR2衍生物的气相色谱测定法]

[A GLC assay method for chlorimipramine and its NOR1 and NOR2 derivatives in plasma].

作者信息

Megazzini I, Wondrak G, Puliti R, Giovannini M G, Cioni P, Della Corte L, Sgaragli G P

出版信息

Boll Soc Ital Biol Sper. 1980 Dec 15;56(23):2518-20.

PMID:7470295
Abstract

A method is described for assaying by GLC the mono- and di-N-demethyl derivatives of chlorimipramine. This was performed by N-acylating the compounds with pentafluoropropionic anhydride and pyridine.

摘要

描述了一种通过气相色谱法（GLC）测定氯米帕明单-N-去甲基衍生物和双-N-去甲基衍生物的方法。该方法是通过用五氟丙酸酐和吡啶对化合物进行N-酰化来实现的。

相似文献

1
[A GLC assay method for chlorimipramine and its NOR1 and NOR2 derivatives in plasma].[血浆中氯米帕明及其NOR1和NOR2衍生物的气相色谱测定法]
Boll Soc Ital Biol Sper. 1980 Dec 15;56(23):2518-20.
2
[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].[一种采用氮磷检测器的微分析气液色谱法用于测定各种三环结构精神药物及其N-去甲基代谢产物]
Boll Soc Ital Biol Sper. 1984 Sep 30;60(9):1757-63.
3
Isothermal gas chromatographic determination of nanogram amounts of chlorimipramine, chlorpromazine and their N-desmethyl metabolites in plasma using nitrogen-selective detection.采用氮选择性检测的等温气相色谱法测定血浆中纳克量的氯米帕明、氯丙嗪及其N-去甲基代谢物。
J Chromatogr. 1986 Sep 5;381(2):315-22. doi: 10.1016/s0378-4347(00)83597-5.
4
[N-dealkylation of chlorimipramine and chlorpromazine in patients undergoing chronic treatment with both drugs: preliminary results].
Boll Soc Ital Biol Sper. 1984 Sep 30;60(9):1727-33.
5
Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression.抑郁症治疗期间氯米帕明及其去甲基代谢物的血浆水平。
Clin Pharmacol Ther. 1979 Nov;26(5):600-10. doi: 10.1002/cpt1979265600.
6
A sensitive and specific method for the determination of chlorimipramine and desmethylchlorimipramine in plasma using selected ion monitoring with chemical ionization.一种采用化学电离选择离子监测法测定血浆中氯米帕明和去甲氯米帕明的灵敏且特异的方法。
Biomed Mass Spectrom. 1980 Nov;7(11-12):588-91. doi: 10.1002/bms.1200071128.
7
Ion-pair liquid chromatography of steady-state plasma levels of chlorimipramine and demethylchlorimipramine.氯米帕明和去甲基氯米帕明稳态血浆水平的离子对液相色谱法
J Chromatogr. 1977 Nov 1;143(6):597-605. doi: 10.1016/s0378-4347(00)81314-6.
8
Determination of chlorimipramine and desmethylchlorimipramine in human plasma by ion-pair partition chromatography.采用离子对分配色谱法测定人血浆中氯米帕明和去甲氯米帕明的含量。
J Chromatogr. 1976 Jan 21;116(2):475-9. doi: 10.1016/s0021-9673(00)89922-7.
9
Nonlinear pharmacokinetics of chlorimipramine after infusion and oral administration in patients.氯米帕明在患者输注和口服给药后的非线性药代动力学。
Prog Neuropsychopharmacol Biol Psychiatry. 1986;10(6):739-48. doi: 10.1016/0278-5846(86)90059-x.
10
A sensitive method for the simultaneous determination in biological fluids of imipramine and desipramine or clomipramine and N-desmethylclomipramine by gas chromatography mass spectrometry.一种通过气相色谱-质谱联用技术同时测定生物体液中丙咪嗪与去甲丙咪嗪或氯米帕明与N-去甲基氯米帕明的灵敏方法。
Biomed Mass Spectrom. 1979 May;6(5):200-4. doi: 10.1002/bms.1200060506.