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测量降钙素正常循环水平的基本步骤。

Essential steps in the measurement of normal circulating levels of calcitonin.

作者信息

MacIntyre I, Girgis S I, Hillyard C J

出版信息

Biomed Pharmacother. 1984;38(5):230-4.

PMID:6525416
Abstract

Before interpreting the results of assays which claim to measure circulating levels, one must have full data on the sensitivity, the reproducibility and specificity of the methods and antisera used. Without this information figures are meaningless and may be regarded as fiction rather than science. Secondly, and of equal importance, one must have full details of those physiological and pharmacological factors which are known to affect the circulating levels. It is quite obvious to workers in the field that those laboratories which have paid attention to these matters, have achieved remarkable agreement in practice; those who have neglected these requirements have introduced quite unnecessary confusion in the literature.

摘要

在解读那些声称可测量循环水平的检测结果之前,必须掌握所使用方法和抗血清的敏感性、可重复性及特异性的完整数据。没有这些信息,数据便毫无意义,可能会被视为虚构内容而非科学依据。其次,同样重要的是,必须详细了解那些已知会影响循环水平的生理和药理因素。该领域的工作人员很清楚,那些关注这些事项的实验室在实际操作中达成了显著的共识;而那些忽视这些要求的实验室则在文献中造成了相当不必要的混乱。

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引用本文的文献

1
Calcitonin as Biomarker for the Medullary Thyroid Carcinoma.降钙素作为甲状腺髓样癌的生物标志物。
Recent Results Cancer Res. 2025;223:155-182. doi: 10.1007/978-3-031-80396-3_6.
2
Calcitonin gene-related peptide: endocrine distribution and characterization of circulating forms.降钙素基因相关肽:内分泌分布及循环形式的特征
J Endocrinol Invest. 1989 Nov;12(10):699-704. doi: 10.1007/BF03350036.
3
A new approach for calcitonin determination based on target cell responsiveness.一种基于靶细胞反应性的降钙素测定新方法。
J Endocrinol Invest. 1990 Feb;13(2):119-26. doi: 10.1007/BF03349520.