Heath H, Body J J, Fox J
Biomed Pharmacother. 1984;38(5):241-5.
Radioimmunoassay of calcitonin in normal human plasma is hindered by immunochemical heterogeneity in plasma, variable susceptibility of antisera to non-specific factors, limited assay sensitivity, and other problems. Many controversial points in the literature arise from these difficulties. Measurement of calcitonin after various extraction procedures yields greater consistency of results. Recent advances in calcitonin assay technology offer the promise of measuring calcitonin monomer with sufficient sensitivity to permit studies of normal calcitonin physiology and of the hormone's role in human disease.
正常人血浆中降钙素的放射免疫测定受到血浆中免疫化学异质性、抗血清对非特异性因素的易感性变化、测定灵敏度有限以及其他问题的阻碍。文献中许多有争议的观点都源于这些困难。经过各种提取程序后测定降钙素，结果的一致性更高。降钙素测定技术的最新进展有望以足够的灵敏度测量降钙素单体，从而能够研究正常降钙素生理学以及该激素在人类疾病中的作用。
