Cecchettin M, Tarquini B
Biomed Pharmacother. 1984;38(5):252-5.
Calcitonin seasonal (circannual) variations in apparently healthy women and in women suffering from breast cancer in different evolutive-TNM-stage, were studied. Annual values are higher in patients with breast cancer, but there is no correlation with metastases. A significant calcitonin circannual rhythm with acrophase in winter was detectable in controls but not in breast cancer patients. The circannual rhythm obliteration could be a predictive signal of disease and not only metastatic disease.
对表面健康的女性以及处于不同TNM分期演变阶段的乳腺癌女性患者体内降钙素的季节性（周年性）变化进行了研究。乳腺癌患者的年度值较高，但与转移情况无关。在对照组中可检测到降钙素具有冬季高峰期的显著周年节律，而乳腺癌患者中则未检测到。周年节律消失可能是疾病的预测信号，而不仅仅是转移性疾病的预测信号。
