Krisch B, Leonhardt H, Oksche A
Cell Tissue Res. 1984;238(3):459-74. doi: 10.1007/BF00219861.
The intercellular clefts of the brain and the leptomeninges, and the perivascular spaces were studied with reference to the results obtained in a previous study (Krisch et al. 1983). The spatial relationships of these compartments were analyzed at the electron-microscopic level. Horseradish peroxidase (HRP) was injected into the brain or into the contralateral ventricle. The pattern of distribution of HRP depends on the boundary situation in the individual compartments. The inner and outer pial layers accompany the vessels intruding into the brain. In the Virchow-Robin space the pial funnel obliterates within a short distance. The inner arachnoid layer is continuous with the outer arachnoid layer when it covers the vessels traversing the meningeal space. The perivascular compartment is not in communication with the arachnoid space; moreover, the pial funnel within the Virchow-Robin space is sealed off against the arachnoid space. Thus, blood vessels traversing the meningeal spaces and subsequently penetrating the brain surface are exposed to the common intercellular compartment represented by the intercellular clefts of the brain and the leptomeninges; this compartment does not communicate with the other compartments. The cerebrospinal fluid located in this intercellular compartment is preferentially drained into the upper cervical lymph nodes.
参照先前研究（Krisch等人，1983年）所得结果，对脑和软脑膜的细胞间裂隙以及血管周围间隙进行了研究。在电子显微镜水平分析了这些腔隙的空间关系。将辣根过氧化物酶（HRP）注入脑内或对侧脑室。HRP的分布模式取决于各个腔隙中的边界情况。软脑膜的内层和外层伴随着侵入脑内的血管。在Virchow-Robin间隙中，软脑膜漏斗在短距离内消失。当蛛网膜内层覆盖穿过脑膜间隙的血管时，它与蛛网膜外层相连。血管周围腔隙与蛛网膜下腔不连通；此外，Virchow-Robin间隙内的软脑膜漏斗与蛛网膜下腔是封闭的。因此，可以穿过脑膜间隙并随后穿透脑表面的血管暴露于由脑和软脑膜的细胞间裂隙所代表的共同细胞间腔隙中；该腔隙与其他腔隙不连通。位于这个细胞间腔隙中的脑脊液优先引流到上颈部淋巴结。
