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PC13胚胎癌衍生生长因子。

PC13 embryonal carcinoma-derived growth factor.

作者信息

Heath J K, Isacke C M

出版信息

EMBO J. 1984 Dec 1;3(12):2957-62. doi: 10.1002/j.1460-2075.1984.tb02240.x.

DOI:10.1002/j.1460-2075.1984.tb02240.x
PMID:6526007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC557797/
Abstract

A potent growth factor, PC13 embryonal carcinoma-derived growth factor (ECDGF), has been isolated from serum-free medium conditioned by PC13 murine embryonal carcinoma cells. ECDGF is a single chain, cationic hydrophobic molecule of 17 500 daltons. ECDGF will induce DNA synthesis in established fibroblast cell lines and the immediate differentiated progeny of PC13 EC cells in vitro, and consequently appears to differ from other well characterised growth factors both in structure and action.

摘要

一种强效生长因子，即PC13胚胎癌细胞衍生生长因子（ECDGF），已从PC13小鼠胚胎癌细胞条件培养的无血清培养基中分离出来。ECDGF是一种分子量为17500道尔顿的单链阳离子疏水分子。ECDGF在体外可诱导已建立的成纤维细胞系以及PC13胚胎癌细胞的直接分化后代进行DNA合成，因此在结构和作用方面似乎与其他已明确特征的生长因子有所不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a48/557797/d59c8fc4ebad/emboj00316-0233-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a48/557797/d59c8fc4ebad/emboj00316-0233-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a48/557797/d59c8fc4ebad/emboj00316-0233-a.jpg

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引用本文的文献

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2
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本文引用的文献

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines.对培养的小鼠胚胎细胞生长及其发育成既定细胞系的定量研究。
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Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition.血小板衍生生长因子。通过大规模方法进行分离及亚基组成分析。
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Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein.
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Autocrine growth induced by the insulin-related factor in the insulin-independent teratoma cell line 1246-3A.胰岛素非依赖型畸胎瘤细胞系1246-3A中胰岛素相关因子诱导的自分泌生长。
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Isolation and characterization of a multiplication-stimulating activity (MSA)-like polypeptide produced by a human fibrosarcoma cell line.
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Clonal analysis of the change in growth phenotype during embryonal carcinoma cell differentiation.胚胎癌细胞分化过程中生长表型变化的克隆分析。
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