PC13胚胎癌衍生生长因子。
PC13 embryonal carcinoma-derived growth factor.
作者信息
Heath J K, Isacke C M
出版信息
EMBO J. 1984 Dec 1;3(12):2957-62. doi: 10.1002/j.1460-2075.1984.tb02240.x.
A potent growth factor, PC13 embryonal carcinoma-derived growth factor (ECDGF), has been isolated from serum-free medium conditioned by PC13 murine embryonal carcinoma cells. ECDGF is a single chain, cationic hydrophobic molecule of 17 500 daltons. ECDGF will induce DNA synthesis in established fibroblast cell lines and the immediate differentiated progeny of PC13 EC cells in vitro, and consequently appears to differ from other well characterised growth factors both in structure and action.
一种强效生长因子，即PC13胚胎癌细胞衍生生长因子（ECDGF），已从PC13小鼠胚胎癌细胞条件培养的无血清培养基中分离出来。ECDGF是一种分子量为17500道尔顿的单链阳离子疏水分子。ECDGF在体外可诱导已建立的成纤维细胞系以及PC13胚胎癌细胞的直接分化后代进行DNA合成，因此在结构和作用方面似乎与其他已明确特征的生长因子有所不同。
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