Hollick G E, Nolte F S, Calnan B J, Penner J L, Barton L J, Spellacy A
Eur J Clin Microbiol. 1984 Dec;3(6):521-5. doi: 10.1007/BF02013611.
Providencia stuartii has emerged as a significant nosocomial urinary tract pathogen. An increase in the number of Providencia isolates from urine cultures prompted an investigation into the possibility of an outbreak due to this organism. A high proportion of patients studied had urinary devices. Four wards were screened at two time periods to ascertain the prevalence of Providencia stuartii in urine cultures. Biotype, serotype, antibiogram and plasmid content were determined for each Providencia isolate. Of 129 patients initially sampled 22.5% were found to harbor Providencia stuartii. Biotyping, serotyping and antibiograms indicated an epidemic strain was not present. Similar results were obtained when the wards were screened a second time, with 25.4% of urine cultures found to contain Providencia stuartii. By plasmid analysis the isolates could be grouped into one of ten profiles. A correlation could be made between urease activity and the presence of a large plasmid. No association however could be made between a particular plasmid profile and antibiogram. The data indicate that an epidemic strain of Providencia stuartii was not present. The source(s) of the endemic Providencia stuartii strains remain unknown.
斯氏普罗威登斯菌已成为一种重要的医院获得性泌尿道病原体。尿液培养中分离出的斯氏普罗威登斯菌数量增加，促使对该病原体引发疫情的可能性展开调查。研究的患者中有很大一部分使用了导尿装置。在两个时间段对四个病房进行了筛查，以确定尿液培养中斯氏普罗威登斯菌的流行情况。对每株斯氏普罗威登斯菌进行了生物分型、血清分型、药敏谱和质粒含量测定。在最初采样的129名患者中，发现22.5%携带斯氏普罗威登斯菌。生物分型、血清分型和药敏谱表明不存在流行菌株。当对病房进行第二次筛查时，得到了类似的结果，发现25.4%的尿液培养物中含有斯氏普罗威登斯菌。通过质粒分析，分离株可分为十种图谱之一。脲酶活性与大质粒的存在之间存在相关性。然而，特定的质粒图谱与药敏谱之间没有关联。数据表明不存在斯氏普罗威登斯菌的流行菌株。地方性斯氏普罗威登斯菌菌株的来源仍然未知。
