McHale P J, Keane C T, Dougan G
J Clin Microbiol. 1981 Jun;13(6):1099-104. doi: 10.1128/jcm.13.6.1099-1104.1981.
A total of 238 isolates of Providencia stuartii obtained from infected patients in six Dublin hospitals were grouped by using serological and bacteriocin typing methods and tested for sensitivity to a number of antimicrobial agents. Most isolates were resistant to several of these agents. Resistance to tetracycline, resistance to penicillin, resistance to polymyxin, and probably resistance to nitrofurantoin was intrinsic. Plasmid screening coupled with resistance transfer studies showed that both chromosome-encoded and plasmid-coded resistance mechanisms were clinically important. Ampicillin resistance was both chromosomally and plasmid encoded, whereas resistance to kanamycin and resistance to carbenicillin were exclusively plasmid encoded. Gentamicin resistance was more common than kanamycin resistance, and although gentamicin-resistant strains contained aminoglycoside acetyltransferase activity, no association could be demonstrated with plasmid deoxyribonucleic acid in the strains tested. Unlike minimal inhibitory concentrations for kanamycin, minimal inhibitory concentrations for gentamicin varied over a wide range. P. stuartii isolated obtained from several different countries were tested for comparison. As a group, these strains were less resistant, but they did exhibit similar resistance properties.
从都柏林六家医院的感染患者中分离出238株斯氏普罗威登斯菌，采用血清学和细菌素分型方法进行分组，并检测其对多种抗菌药物的敏感性。大多数分离株对其中几种药物耐药。对四环素、青霉素、多粘菌素的耐药性以及可能对呋喃妥因的耐药性是固有耐药。质粒筛选与耐药性转移研究表明，染色体编码和质粒编码的耐药机制在临床上都很重要。氨苄西林耐药性既有染色体编码也有质粒编码，而对卡那霉素和羧苄西林的耐药性仅由质粒编码。庆大霉素耐药性比卡那霉素耐药性更常见，尽管耐庆大霉素菌株含有氨基糖苷乙酰转移酶活性，但在所测试的菌株中未发现与质粒脱氧核糖核酸有关联。与卡那霉素的最低抑菌浓度不同，庆大霉素的最低抑菌浓度变化范围很广。对从几个不同国家分离得到的斯氏普罗威登斯菌进行了测试以作比较。作为一个群体，这些菌株耐药性较低，但它们确实表现出相似的耐药特性。
