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[青少年梗死患者的长期预后。随访结果]

[Long-term prognosis of patients with juvenile infarct. Catamnestic results].

作者信息

Auff E, Schnaberth G, Zeiler K

出版信息

Eur Arch Psychiatry Neurol Sci. 1984;234(4):275-80. doi: 10.1007/BF00381360.

Abstract

Seventy patients suffering from ischemic cerebrovascular disease had had their first attack before the age of 40 years. Of these patients 57 were re-examined 84 months (mean) after the initial event. Within 48 months, 22 of 51 patients (43.1%) without surgical treatment had recurrent ischemic events (78.6% patients with transient ischemic attacks, 33.3% patients with protracted reversible deficits, 28.6% patients with completed stroke). Of all patients 31.5% had their first recurrent attack during the first year, most of them during the first few months after the initial event. In spite of the considerably higher recurrence rate, patients with initial transient ischemic attacks or protracted reversible deficits had a lower degree of social disability at the end of the follow-up period than patients with an initial completed stroke. In 72.2% of the patients with recurrent events the ischemic focus was found in a vascular area different from the one originally concerned. Patients with arterial hypertension during the follow-up period had a somewhat less-favorable long-term prognosis, but nicotine abuse or relative body weight had no influence on the degree of social disability at the end of the follow-up period. In general, long-term prognosis was rather favorable, 78.4% of the patients being fully capable of work at the end of the follow-up period. Nevertheless, results point to the necessity of complete diagnostic evaluation without delay and introduction of individual therapy for patients suffering from "juvenile stroke."

摘要

70例缺血性脑血管疾病患者首次发病年龄在40岁之前。这些患者中有57例在首次发病后84个月(平均)接受了复查。在48个月内,51例未接受手术治疗的患者中有22例(43.1%)发生了复发性缺血事件(78.6%为短暂性脑缺血发作患者,33.3%为迁延性可逆性缺损患者,28.6%为完全性卒中患者)。在所有患者中,31.5%在第一年发生了首次复发,其中大多数在首次发病后的头几个月内。尽管复发率相当高,但初始为短暂性脑缺血发作或迁延性可逆性缺损的患者在随访期末的社会残疾程度低于初始为完全性卒中的患者。在72.2%的复发事件患者中,缺血病灶位于与最初受累血管区域不同的血管区域。随访期间患有动脉高血压的患者长期预后略差,但尼古丁滥用或相对体重对随访期末的社会残疾程度没有影响。总体而言,长期预后相当良好,78.4%的患者在随访期末完全能够工作。然而,结果表明对于“青少年卒中”患者必须立即进行全面的诊断评估并采用个体化治疗。

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