Ohgaki H, Kato T, Morino K, Matsukura N, Sato S, Takayama S, Sugimura T
Gan. 1984 Dec;75(12):1053-7.
The effect of sodium chloride on the promotion stage of gastric carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was studied in male inbred Wistar rats. Rats in group I were given MNNG at a concentration of 50 micrograms/ml in their drinking water for 12 weeks and then 1 ml of saturated NaCl solution intragastrically once a week until experimental week 65. Rats in group II were given MNNG for 12 weeks and then 1 ml of distilled water intragastrically once a week until week 65. Rats in group III were not treated for the first 12 weeks and were then given 1 ml of saturated NaCl solution intragastrically once a week until week 65. The incidence of adenomatous hyperplasias in the glandular stomach was significantly higher in group I than in group II, but the incidences of gastric adenocarcinomas and adenomas in groups I and II were not significantly different. No neoplastic or preneoplastic changes were observed in the stomach in group III.
研究了氯化钠对N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱发雄性近交系Wistar大鼠胃癌促癌阶段的影响。第一组大鼠饮用含浓度为50微克/毫升MNNG的水12周，然后每周一次胃内注射1毫升饱和氯化钠溶液，直至实验第65周。第二组大鼠给予MNNG 12周，然后每周一次胃内注射1毫升蒸馏水，直至第65周。第三组大鼠在最初12周不进行处理，然后每周一次胃内注射1毫升饱和氯化钠溶液，直至第65周。第一组腺胃腺瘤样增生的发生率显著高于第二组，但第一组和第二组胃腺癌和腺瘤的发生率无显著差异。第三组大鼠胃内未观察到肿瘤性或癌前病变。
