Smit D A, Essed G G, de Haan J
Gynecol Obstet Invest. 1984;18(5):252-63. doi: 10.1159/000299090.
A longitudinal investigation regarding the serum concentrations of oestradiol, oestriol and progesterone in relation to uterine activity has been performed in 80 healthy primigravid women during the course of pregnancy up to the 37th week of pregnancy. The frequency of uterine contractions was quantitatively objectivated by means of external toco-dynamometry; simultaneously the uterine activity has been recorded by the pregnant women qualitatively. It appears that there is a gradual increase of all the three mentioned hormones during the course of pregnancy. However, there is a large interindividual spread. There exists no relation between the hormonal serum levels and uterine activity (quantitatively as well as qualitatively recorded). Between these two latter there is a poor relation. It is impossible to predict the occurrence of preterm birth based on hormonal serum changes. This holds for the progesterone-oestradiol ratio.
对80名健康初孕妇进行了一项纵向研究，观察孕期直至妊娠第37周时血清雌二醇、雌三醇和孕酮浓度与子宫活动的关系。子宫收缩频率通过外部宫缩动力学定量测定；同时，孕妇对子宫活动进行了定性记录。结果显示，在孕期这三种激素均逐渐升高。然而，个体间差异很大。激素血清水平与子宫活动（定量及定性记录）之间不存在关联。这两者之间关系甚微。基于激素血清变化无法预测早产的发生。孕酮 - 雌二醇比值亦是如此。
