制备一种在体内稳定的211At-IgG偶联物。
Preparation of a 211At-IgG conjugate which is stable in vivo.
作者信息
Harrison A, Royle L
出版信息
Int J Appl Radiat Isot. 1984 Nov;35(11):1005-8. doi: 10.1016/0020-708x(84)90001-2.
PMID:6526518
Abstract
The short lived (t 1/2 7.2 h) alpha-particle emitting halogen 211At has been attached to an antibody by using an acylation reaction to conjugate para-[211At]astato-benzoic acid with rabbit IgG. The conjugate, which is stable in vivo, contains at least 30% of the initial activity of 211At.
摘要
半衰期较短（t1/2为7.2小时）且发射α粒子的卤素211砹，已通过酰化反应将对-[211砹]砹苯甲酸与兔免疫球蛋白G共轭，从而附着于一种抗体上。这种共轭物在体内稳定，含有至少30%的211砹初始活性。
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