Pérez H A, Bolívar J, San Blas G
J Immunopharmacol. 1984;6(4):305-21. doi: 10.3109/08923978409028606.
The effect of yeast beta-1, 3-glucan as an immunopotentiator of delayed type-hypersensitivity reactions (DHR) was studied. Delayed-type-hypersensitivity reactions in mice sensitized intraperitoneally (IP) with sheep red blood cells (SRBC) and pretreated three days previously with glucan given IP were significantly increased. However, mice sensitized IP with SRBC three days after the subcutaneous (SC) administration of glucan showed depressed DHR. Glucan given at the same site but not at distance strongly potentiated the DHR induced by SC sensitization with SRBC. Subcutaneous injection of glucan and SRBC given together also resulted in a sustained DHR which persisted twelve days after sensitization when DHR of control mice had waned.
研究了酵母β-1,3-葡聚糖作为迟发型超敏反应（DHR）免疫增强剂的作用。用绵羊红细胞（SRBC）腹腔内（IP）致敏且三天前腹腔注射葡聚糖预处理的小鼠，其迟发型超敏反应显著增强。然而，皮下（SC）注射葡聚糖三天后腹腔注射SRBC致敏的小鼠，其DHR受到抑制。在同一部位而非远处给予葡聚糖能强烈增强由皮下注射SRBC致敏诱导的DHR。皮下同时注射葡聚糖和SRBC也会导致持续的DHR，致敏后12天仍存在，而此时对照小鼠的DHR已减弱。
