Carlson R P, Blazek E M, Datko L J, Lewis A J
J Immunopharmacol. 1984;6(4):379-88. doi: 10.3109/08923978409028610.
Collagen arthritis in rats has a well defined humoral and cellular immunologic response to type II collagen, the inciting antigen. Like other chronic models of inflammation, considerable variation exists in terms of severity and incidence. We have attempted to correlate the inflammatory response as measured by paw volume, with serum type II collagen antibody and skin delayed hypersensitivity (DH) to type II collagen. Surprisingly, the incidence and severity of collagen arthritis, induced in the presence of MDP to increase incidence of the disease, are neither correlated with type II collagen antibody nor DH to type II collagen. However, tarsometatarsal bone erosion is significantly correlated with paw edema. Further studies will be necessary to elucidate the role of both humoral and cellular immune responses in the development of type II collagen arthritis in the rat.
大鼠胶原性关节炎对激发抗原Ⅱ型胶原具有明确的体液和细胞免疫反应。与其他慢性炎症模型一样，在严重程度和发病率方面存在相当大的差异。我们试图将通过爪体积测量的炎症反应与血清Ⅱ型胶原抗体以及对Ⅱ型胶原的皮肤迟发型超敏反应（DH）相关联。令人惊讶的是，在存在MDP以增加疾病发病率的情况下诱导的胶原性关节炎的发病率和严重程度，既与Ⅱ型胶原抗体无关，也与对Ⅱ型胶原的DH无关。然而，跗跖骨侵蚀与爪水肿显著相关。需要进一步研究以阐明体液和细胞免疫反应在大鼠Ⅱ型胶原性关节炎发展中的作用。
