Chang Y H, Iizuka Y
Agents Actions. 1984 Dec;15(5-6):529-34. doi: 10.1007/BF01966768.
The severity of type II collagen-induced arthritis was found to correlate with the serum titers of anti-type II collagen antibody, but not with cell-mediated immunity to type II collagen. In contrast, no significant levels of either the humoral or the cell-mediated immunity to type II collagen were found in rats with Freund's complete adjuvant-induced arthritis. Pre-treatment of young rats with an oily preparation of type II collagen prevented the development of arthritis in these animals in response to a subsequent injection of oily preparation of type II collagen, but had no effect on the development of arthritis in response to a subsequent injection of Freund's complete adjuvant. It is concluded that while an immune response directed toward the injected type II collagen is responsible for the development of type II collagen arthritis, it does not play an important role in the induction of Freund's adjuvant-induced arthritis.
研究发现，II型胶原诱导的关节炎严重程度与抗II型胶原抗体的血清滴度相关，但与针对II型胶原的细胞介导免疫无关。相比之下，在弗氏完全佐剂诱导的关节炎大鼠中，未发现针对II型胶原的体液免疫或细胞介导免疫的显著水平。用II型胶原油剂预处理幼鼠，可防止这些动物在随后注射II型胶原油剂时发生关节炎，但对随后注射弗氏完全佐剂引起的关节炎发展没有影响。结论是，虽然针对注射的II型胶原的免疫反应是II型胶原关节炎发展的原因，但它在弗氏佐剂诱导的关节炎诱导中不起重要作用。
