Mason R M, Palfrey A J
J Orthop Res. 1984;2(4):333-8. doi: 10.1002/jor.1100020405.
Breeding experiments confirmed that a hereditary form of kyphoscoliosis in the BDL strain mouse was due to an autosomal recessive gene (ky). Sagittal sections of whole vertebral columns from adult homozygous recessive mice (ky/ky) were examined histologically. All mice showed varying degrees of degenerative change in one or more intervertebral discs between the fifth cervical and the second thoracic vertebrae. The changes comprised loss of cells, loss of distinction between nucleus pulposus and annulus fibrosus, loss of characteristic ring-like structure in the annulus, and development of wedge-shaped discs. In most animals, degenerative disc substance protruded from the disc space, usually posteriorly, sometimes anteriorly, and occasionally through the vertebral end plate cartilage. Posterior protrusions impinged on the spinal cord.
育种实验证实，BDL品系小鼠的一种遗传性脊柱后凸侧弯形式是由常染色体隐性基因（ky）所致。对成年纯合隐性小鼠（ky/ky）的整个脊柱矢状切片进行了组织学检查。所有小鼠在第五颈椎和第二胸椎之间的一个或多个椎间盘均呈现出不同程度的退行性变化。这些变化包括细胞丢失、髓核与纤维环之间界限消失、纤维环特征性环状结构丧失以及椎间盘呈楔形。在大多数动物中，退变的椎间盘物质从椎间盘间隙突出，通常向后，有时向前，偶尔穿过椎体终板软骨。向后的突出物压迫脊髓。
