Lehmann P A, Favari L
J Toxicol Clin Toxicol. 1984;22(4):331-9. doi: 10.3109/15563658408992564.
Activated charcoal and Prussian blue are effective antidotes in acute thallium (T1+) intoxication in rats. They act by trapping any metal present in or secreted into the gut by the gastro-intestinal epithelium. It was therefore of interest to determine the parameters of the Langmuir adsorption isotherms of T1+ ions for these two adsorbents. The data from equilibration experiments were analyzed by direct least-squares fitting to a hyperbola and with Langmuir's equation to give the following results: Activated charcoal: K1(-1) = 192 micrograms ml-1, K2 = 124 mg g-1 Prussian Blue: K1(-1) = 130 micrograms ml-1, K2 = 72 mg g-1. These high values provide in vitro confirmation of their in vivo antidotal efficacy and show that activated charcoal can replace Prussian blue when this latter drug is unobtainable.
活性炭和普鲁士蓝是大鼠急性铊（Tl⁺）中毒的有效解毒剂。它们通过捕获胃肠道上皮细胞存在于肠道或分泌到肠道中的任何金属来发挥作用。因此，确定这两种吸附剂对Tl⁺离子的朗缪尔吸附等温线参数很有意义。通过直接最小二乘法拟合双曲线和朗缪尔方程对平衡实验数据进行分析，得到以下结果：活性炭：K₁⁻¹ = 192微克/毫升，K₂ = 124毫克/克；普鲁士蓝：K₁⁻¹ = 130微克/毫升，K₂ = 72毫克/克。这些高数值在体外证实了它们的体内解毒效果，并表明当无法获得普鲁士蓝时，活性炭可以替代它。
