Mori N, Murase T, Yamada N, Arakawa N, Takaku F
Lipids. 1984 Dec;19(12):978-81. doi: 10.1007/BF02534738.
Guinea pigs have varying plasma triglyceride concentrations ranging from 28 to 1392 mg/dl, with relatively uniform plasma cholesterol and phospholipid levels. To understand why the animals exhibit such wide variations of plasma triglyceride concentrations, we have explored the triglyceride hydrolyzing system by measuring tissue lipoprotein lipase activities and plasma activator for the enzyme. Lipoprotein lipase activities of epididymal adipose tissue of these animals were 759 +/- 117 (mean +/- SE) n moles FFA X min-1 X g wet tissue-1, markedly low compared with those of rats. There were no relationships between plasma triglyceride concentrations and tissue lipase activities. Plasma activator for lipoprotein lipase was lacking in this animal. Guinea pigs with ascorbic acid deficiency for 2 weeks also showed marked variations of plasma triglyceride concentrations, without any changes in tissue lipoprotein lipase activities. Low adipose tissue lipoprotein lipase activities with deficient plasma activator for the enzyme suggest that the lipoprotein lipase-mediated triglyceride degradation could be impaired in this animal, and this may account for the marked variation of plasma triglyceride concentrations.
豚鼠的血浆甘油三酯浓度变化范围为28至1392毫克/分升，血浆胆固醇和磷脂水平相对一致。为了解这些动物为何表现出血浆甘油三酯浓度如此广泛的变化，我们通过测量组织脂蛋白脂肪酶活性和该酶的血浆激活剂来探究甘油三酯水解系统。这些动物附睾脂肪组织的脂蛋白脂肪酶活性为759±117（平均值±标准误）纳摩尔游离脂肪酸×分钟-1×克湿组织-1，与大鼠相比明显较低。血浆甘油三酯浓度与组织脂肪酶活性之间没有关系。这种动物缺乏脂蛋白脂肪酶的血浆激活剂。缺乏抗坏血酸两周的豚鼠也表现出血浆甘油三酯浓度的显著变化，而组织脂蛋白脂肪酶活性没有任何变化。脂肪组织脂蛋白脂肪酶活性低且缺乏该酶的血浆激活剂表明，这种动物中脂蛋白脂肪酶介导的甘油三酯降解可能受损，这可能解释了血浆甘油三酯浓度的显著变化。
