van Heuven-Nolsen D, De Kloet E R, Versteeg D H
Neuropharmacology. 1984 Dec;23(12A):1373-7. doi: 10.1016/0028-3908(84)90075-3.
The effects of oxytocin, administered intracerebroventricularly in doses of 1, 10, 100 and 1000 pmol, were studied on the disappearance of catecholamines induced by alpha-methyl-p-tyrosine in microdissected nuclei of the rat brain. Oxytocin dose-dependently decreased the utilization of noradrenaline in the lateral and medial septal nuclei and anterior hypothalamic area, whereas an enhanced utilization was observed in the nucleus supraopticus. Tendency towards a change in utilization of noradrenaline was found in the dorsal septal nucleus and the lateral amygdala. Utilization of dopamine was not significantly affected in any of the nuclei of the brain studied. Tendency towards a decrease in utilization of dopamine was observed in the nucleus caudatus, globus pallidus and medial septal nucleus. It thus appears that oxytocin elicited changes in only a restricted number of brain nuclei. Interestingly, these nuclei contain cell bodies (nucleus supraopticus) and terminals (other nuclei) of the oxytocin system in the brain. Though the effects of oxytocin were not as widespread as those previously seen after administration of vasopressin, it is worthy of note that, in general, the effects of oxytocin were opposite to those seen after vasopressin. The opposite effects of vasopressin and oxytocin on catecholamine metabolism could be related to the opposite effects of the two peptides on behaviour, neuroendocrine and autonomic regulation.
研究了脑室内注射剂量为1、10、100和1000皮摩尔的催产素对大鼠脑显微切割核中由α-甲基-p-酪氨酸诱导的儿茶酚胺消失的影响。催产素剂量依赖性地降低了外侧和内侧隔核以及下丘脑前区去甲肾上腺素的利用率，而在视上核中观察到利用率增加。在背侧隔核和外侧杏仁核中发现了去甲肾上腺素利用率变化的趋势。在所研究的脑的任何核中，多巴胺的利用率均未受到显著影响。在尾状核、苍白球和内侧隔核中观察到多巴胺利用率有降低的趋势。因此，催产素似乎仅在有限数量的脑核中引起变化。有趣的是，这些核包含脑中催产素系统的细胞体（视上核）和终末（其他核）。尽管催产素的作用不如先前注射加压素后那么广泛，但值得注意的是，一般而言，催产素的作用与加压素的作用相反。加压素和催产素对儿茶酚胺代谢的相反作用可能与这两种肽对行为、神经内分泌和自主调节的相反作用有关。
