Kovács G L, Faludi M, Telegdy G
Psychopharmacology (Berl). 1985;86(3):377-9. doi: 10.1007/BF00432233.
Tolerance was induced in mice to the antinociceptive effect of heroin by repeated subcutaneous injections of this narcotic analgesic for 3 days. Pretreatment of mice with daily doses of oxytocin (2-200 micrograms/kg body wt.) resulted in an attenuation of heroin tolerance. A single oxytocin injection prior to the first challenge with heroin was as active in attenuating heroin tolerance as daily treatments with the neuropeptide. A single injection of oxytocin prior to the least heroin challenge also attenuated the expression of tolerance. The neuropeptide failed to modify the acute antinociceptive effect of heroin. It is concluded, therefore, that oxytocin interferes with mechanisms involved in the development and expression of tolerance to heroin.
通过连续3天对小鼠进行皮下注射海洛因这种麻醉性镇痛药，使其对海洛因的抗伤害感受作用产生耐受性。每日给小鼠注射不同剂量的催产素（2 - 200微克/千克体重）进行预处理，可使海洛因耐受性减弱。在首次用海洛因激发前单次注射催产素，在减弱海洛因耐受性方面与每日用该神经肽治疗的效果相同。在最低剂量海洛因激发前单次注射催产素也能减弱耐受性的表达。该神经肽未能改变海洛因的急性抗伤害感受作用。因此得出结论，催产素干扰了海洛因耐受性形成和表达所涉及的机制。
