• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effect of the alkaloid (-)-cathinone on the release of radioactivity from rat striatal tissue prelabelled with 3H-serotonin.

作者信息

Kalix P

出版信息

Neuropsychobiology. 1984;12(2-3):127-9. doi: 10.1159/000118124.

DOI:10.1159/000118124
PMID:6527753
Abstract

The alkaloid (-)-cathinone, which accounts for the stimulating properties of khat leaves, has a pharmacological profile closely resembling that of (+)-amphetamine. Since amphetamine is known to induce release at CNS serotonin storage sites, experiments were performed to determine whether (-)-cathinone also displays this aspect of amphetamine action. When the effects of (-)-cathinone and (+)-amphetamine on the release of radioactivity from rat striatal tissue prelabelled with 3H-serotonin were compared, it was found that (-)-cathinone had a releasing effect similar to that of (+)-amphetamine, although it was only one third as potent. Thus, the khat alkaloid (-)-cathinone appears to share an important effect of (+)-amphetamine on serotoninergic neurotransmission.

摘要

相似文献

1
Effect of the alkaloid (-)-cathinone on the release of radioactivity from rat striatal tissue prelabelled with 3H-serotonin.
Neuropsychobiology. 1984;12(2-3):127-9. doi: 10.1159/000118124.
2
The amphetamine-like releasing effect of the alkaloid (-)cathinone on rat nucleus accumbens and rabbit caudate nucleus.
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(1):43-9. doi: 10.1016/s0364-7722(82)80106-9.
3
The effect of phenylpentenyl-khatamines on the release of radioactivity from rat striatal tissue prelabelled with [3H]dopamine.
J Pharm Pharmacol. 1987 Feb;39(2):135-7. doi: 10.1111/j.2042-7158.1987.tb06961.x.
4
Cathinone, an alkaloid from khat leaves with an amphetamine-like releasing effect.卡西酮，一种来自巧茶树叶的生物碱，具有类似苯丙胺的释放效应。
Psychopharmacology (Berl). 1981;74(3):269-70. doi: 10.1007/BF00427108.
5
Further evidence for an amphetamine-like mechanism of action of the alkaloid cathinone.
Biochem Pharmacol. 1986 Sep 15;35(18):3015-9. doi: 10.1016/0006-2952(86)90380-1.
6
A constituent of khat leaves with amphetamine-like releasing properties.一种具有类似苯丙胺释放特性的巧茶树叶成分。
Eur J Pharmacol. 1980 Nov 21;68(2):213-5. doi: 10.1016/0014-2999(80)90326-x.
7
Cathinone, a natural amphetamine.
Pharmacol Toxicol. 1992 Feb;70(2):77-86. doi: 10.1111/j.1600-0773.1992.tb00434.x.
8
The releasing effect of the isomers of the alkaloid cathinone at central and peripheral catecholamine storage sites.
Neuropharmacology. 1986 May;25(5):499-501. doi: 10.1016/0028-3908(86)90174-7.
9
A comparison of the behavioral effects of l- and dl-cathinone and d-amphetamine.左旋和消旋去甲伪麻黄碱与右旋苯丙胺行为效应的比较。
J Pharmacol Exp Ther. 1981 Nov;219(2):355-62.
10
Effect of (-)-cathinone, a khat leaf constituent, on dopaminergic firing and dopamine metabolism in the rat brain.
Life Sci. 1983 Mar 21;32(12):1383-9. doi: 10.1016/0024-3205(83)90814-7.

引用本文的文献

1
Effects of congeners of amphetamine on the human heart.安非他命同系物对人体心脏的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul;397(7):4615-4642. doi: 10.1007/s00210-024-02983-2. Epub 2024 Feb 10.
2
Natural Sympathomimetic Drugs: From Pharmacology to Toxicology.天然拟交感神经药物：从药理学到毒理学。
Biomolecules. 2022 Nov 30;12(12):1793. doi: 10.3390/biom12121793.
3
An updated review on synthetic cathinones.合成卡西酮的最新综述。
Arch Toxicol. 2021 Sep;95(9):2895-2940. doi: 10.1007/s00204-021-03083-3. Epub 2021 Jun 8.
4
Neurotoxicity Induced by Mephedrone: An up-to-date Review.甲氧麻黄酮所致神经毒性：最新综述
Curr Neuropharmacol. 2017;15(5):738-749. doi: 10.2174/1570159X14666161130130718.
5
Khat use and appetite: an overview and comparison of amphetamine, khat and cathinone.恰特草的使用与食欲：苯丙胺、恰特草和卡西酮的概述与比较
J Ethnopharmacol. 2015 Feb 3;160:78-85. doi: 10.1016/j.jep.2014.11.002. Epub 2014 Nov 28.
6
Chemistry, pharmacology, and toxicology of khat (catha edulis forsk): a review.巧茶（Catha edulis Forssk）的化学、药理学及毒理学综述
Addict Health. 2011 Summer-Autumn;3(3-4):137-49.
7
Dose-response inhibitory effects of purified cathinone from khat (Catha edulis) on cortisol and prolactin release in vervet monkeys (Chlorocebus aethiops).来自巧茶（Catha edulis）的纯化卡西酮对黑长尾猴（Chlorocebus aethiops）皮质醇和催乳素释放的剂量反应抑制作用。
Metab Brain Dis. 2014 Jun;29(2):451-8. doi: 10.1007/s11011-013-9445-8. Epub 2013 Nov 5.
8
Acute and sub-chronic effects of purified cathinone from khat (Catha edulis) on behavioural profiles in vervet monkeys (Chlorocebus aethiops).来自巧茶（Catha edulis）的纯化去甲伪麻黄碱对绿猴（Chlorocebus aethiops）行为特征的急性和亚慢性影响。
Metab Brain Dis. 2014 Jun;29(2):441-9. doi: 10.1007/s11011-013-9441-z. Epub 2013 Oct 25.
9
Mephedrone, an abused psychoactive component of 'bath salts' and methamphetamine congener, does not cause neurotoxicity to dopamine nerve endings of the striatum.麦角酸二乙胺，一种“浴盐”和冰毒同系物中被滥用的精神活性成分，不会对纹状体的多巴胺神经末梢造成神经毒性。
J Neurochem. 2012 Mar;120(6):1097-107. doi: 10.1111/j.1471-4159.2011.07632.x. Epub 2012 Feb 9.
10
The puzzle of drug-induced conditioned taste aversion: comparative studies with cathinone and amphetamine.
Psychopharmacology (Berl). 1985;87(3):328-33. doi: 10.1007/BF00432716.