Kalix P
Psychopharmacology (Berl). 1981;74(3):269-70. doi: 10.1007/BF00427108.
Khat leaves, widely used as a stimulant in East Africa and the Arab Peninsula, contain the alkaloid (--)-cathinone. The effects of this substance on the efflux of radioactivity from rabbit striatal slices prelabelled with 3H-dopamine were examined. It was found that low concentrations of (--)cathinone enhance the release of radioactivity in a dose-dependent manner, and that (--)cathinone was capable of sustaining the enhanced release induced by (+)amphetamine. Pretreatment of the tissue with cocaine, which is known to prevent the induction of release by (+)amphetamine, inhibited the efflux increase caused by (--)-cathinone. These observations suggest that amphetamine and the active principle of khat leaves have an analogous mechanism of action.
巧茶树叶在东非和阿拉伯半岛被广泛用作兴奋剂，其中含有生物碱（--）-去甲伪麻黄碱。研究了该物质对预先用3H-多巴胺标记的兔纹状体切片放射性流出的影响。结果发现，低浓度的（--）-去甲伪麻黄碱以剂量依赖的方式增强放射性释放，并且（--）-去甲伪麻黄碱能够维持由（+）-苯丙胺诱导的增强释放。已知可卡因可阻止（+）-苯丙胺诱导释放，用可卡因预处理组织可抑制（--）-去甲伪麻黄碱引起的流出增加。这些观察结果表明，苯丙胺和巧茶树叶的活性成分具有类似的作用机制。
