一种具有类似苯丙胺释放特性的巧茶树叶成分。
A constituent of khat leaves with amphetamine-like releasing properties.
作者信息
Kalix P
出版信息
Eur J Pharmacol. 1980 Nov 21;68(2):213-5. doi: 10.1016/0014-2999(80)90326-x.
PMID:7193583
Abstract
Khat leaves, which are widely abused as a stimulant, contain the alkaloid (--)-cathinone. The effect of this compound on the efflux of radioactivity from rabbit striatal tissue prelabelled with [3H]dopamine was examined. (--)-Cathinone enhanced the release of label, and was found to have a potency similar to that of (+)-amphetamine. The observation demonstrates that the khat alkaloid also has amphetamine-like effects at the cellular level.
摘要
作为兴奋剂被广泛滥用的巧茶树叶含有生物碱（--）-去甲伪麻黄碱。研究了该化合物对预先用[3H]多巴胺标记的兔纹状体组织中放射性流出的影响。（--）-去甲伪麻黄碱增强了标记物的释放，并且发现其效力与（+）-苯丙胺相似。该观察结果表明，巧茶生物碱在细胞水平上也具有类似苯丙胺的作用。
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