Band P R, Deschamps M, Falardeau M, Ladouceur J, Cote J
Prev Med. 1984 Sep;13(5):549-54. doi: 10.1016/0091-7435(84)90023-9.
Twelve patients with benign breast disease (BBD) were treated with 150,000 IU of vitamin A daily taken orally. All patients were symptomatic and had measurable or evaluable breast masses. At 3 months of treatment, complete or partial responses were observed in five patients, and marked pain reduction in nine was observed. Side effects were generally mild in nature, consisting mostly of skin and mucosal changes, and were rapidly reversible upon discontinuation of the drug. Treatment was interrupted or discontinued in only two patients, and the dosage of vitamin A was reduced in one on account of toxicity. No hepatotoxicity was observed. Investigation of the chemopreventive role of either vitamin A or retinoids in patients with BBD who are at high risk of developing breast cancer is suggested.
12例患有良性乳腺疾病（BBD）的患者每天口服150,000国际单位的维生素A进行治疗。所有患者均有症状且有可测量或可评估的乳腺肿块。治疗3个月时，5例患者出现完全或部分缓解，9例患者疼痛明显减轻。副作用一般性质较轻，主要包括皮肤和黏膜变化，停药后可迅速逆转。仅2例患者治疗中断或停药，1例因毒性反应减少了维生素A的剂量。未观察到肝毒性。建议对有患乳腺癌高风险的BBD患者中维生素A或类视黄醇的化学预防作用进行研究。
