后侧脑室中3H-5-羟色胺的合成与周转

Synthesis and turnover of 3H-5-hydroxytryptamine in the later cerebroventricle.

作者信息

Kantak K M, Wayner M J, Tilson H A, Dwoskin L P, Stein J M

出版信息

Pharmacol Biochem Behav. 1978 Feb;8(2):153-61. doi: 10.1016/0091-3057(78)90332-5.

Abstract

The lateral cerebroventricle was perfused using two different labelling procedures in three separate experiments on 5-hydroxytryptamine metabolism. The sensitivity of 5-hydroxytryptamine metabolism to various drugs was subsequently determined. The results demonstrate that two serotonin reuptake blockers, imipramine and fluoxetine, increase the efflux of 3h-5-hydroxytryptamine into the ventricle without affecting the efflux of 3H-5-hydroxyindoleacetic acid. BL-3912 A, a drug with weak serotonin agonist activity, also increased the efflux of 3H-5-hydroxytryptamine into the ventricle.

摘要

在三项关于5-羟色胺代谢的独立实验中，采用两种不同的标记方法对侧脑室进行灌注。随后测定了5-羟色胺代谢对各种药物的敏感性。结果表明，两种血清素再摄取阻滞剂丙咪嗪和氟西汀增加了3H-5-羟色胺向脑室的流出量，而不影响3H-5-羟吲哚乙酸的流出量。具有弱血清素激动剂活性的药物BL-3912 A也增加了3H-5-羟色胺向脑室的流出量。