Pryor G T, Larsen F F, Husain S, Braude M C
Pharmacol Biochem Behav. 1978 Mar;8(3):295-318. doi: 10.1016/0091-3057(78)90320-9.
The acute, reciprocal dose-response interactions between delta9-tetrahydrocannabinol (delta9-THC; 2.5, 5.0 and 10.0 mg/kg; IG) and each of three stimulants - d-amphetamine (dA; 1, 2 and 4 mg/kg; IP), cocaine (COC; 10, 20 and 30 mg/kg; IP), and nicotine (NIC; 0.25, 0.5 and 1.0 mg/kg; IP) were studied for their effects on performance of a conditioned avoidance response (CAR), photocell activity, heart rate, body temperature, and rotarod performance. delta9-THC impaired CAR and rotarod performance, depressed photocell activity, and decreased heart rate and body temperature. None of the three stimulants influenced CAR performance, but dA and COC increased the number of intertrial responses, and this latter effect was partially antagonized by delta9-THC. dA and COC, but not NIC, stimulated photocell activity. delta9-THC completely blocked this effect of dA, whereas there was mutual antagonism between delta9-THC and COC on this measure and NIC markedly potentiated the depression caused by delta9-THC. dA and COC tended to offset the impairment of rotarod performance caused by delta9-THC, whereas NIC augmented it. The bradycardia and hypothermia caused by delta9-THC tended to be augmented by these stimulants, especially NIC. The interactions were also studied after subacute treatment for six days with delta9-THC and/or each of the three stimulants. There was evidence for tolerance to the effects of delta9-THC on all measures and this tolerance generally resulted in less interactive effects between delta9-THC and the stimulants. Little or no tolerance was seen for the effects of the three stimulants or their interaction with delta9-THC. The time course of radioactivity derived from 14C-delta9-THC and each of the radiolabelled stimulants was determined in plasma and brain. Only minor interactive effects were found and, in general, they could not account for the functional interactions.
研究了δ9-四氢大麻酚（δ9-THC；2.5、5.0和10.0mg/kg；灌胃）与三种兴奋剂——d-苯丙胺（dA；1、2和4mg/kg；腹腔注射）、可卡因（COC；10、20和30mg/kg；腹腔注射）和尼古丁（NIC；0.25、0.5和1.0mg/kg；腹腔注射）之间的急性、相互剂量反应相互作用，观察其对条件性回避反应（CAR）、光电管活动、心率、体温和转棒试验表现的影响。δ9-THC损害了CAR和转棒试验表现，降低了光电管活动，并降低了心率和体温。三种兴奋剂均未影响CAR表现，但dA和COC增加了试验间反应次数，且δ9-THC部分拮抗了后一种效应。dA和COC，但不是NIC，刺激了光电管活动。δ9-THC完全阻断了dA的这种效应，而在这一指标上，δ9-THC与COC之间存在相互拮抗作用，NIC显著增强了δ9-THC引起的抑制作用。dA和COC倾向于抵消δ9-THC对转棒试验表现的损害，而NIC则增强了这种损害。δ9-THC引起的心动过缓和体温过低倾向于被这些兴奋剂增强，尤其是NIC。还研究了用δ9-THC和/或三种兴奋剂中的每一种进行六天亚急性治疗后的相互作用。有证据表明对δ9-THC对所有指标的影响产生了耐受性，这种耐受性通常导致δ9-THC与兴奋剂之间的相互作用效应减弱。对于三种兴奋剂的作用或它们与δ9-THC的相互作用，几乎没有观察到耐受性。测定了血浆和脑中源自14C-δ9-THC和每种放射性标记兴奋剂的放射性时间进程。仅发现了轻微的相互作用效应，一般来说，它们无法解释功能相互作用。
