Pryor G T, Husain S, Larsen F, McKenzie C E, Carr J D, Braude M C
Pharmacol Biochem Behav. 1977 Jan;6(1):123-36. doi: 10.1016/0091-3057(77)90168-x.
delta9-Tetrahydrocannabinol (THC; 2.5, 5.0, 10.0 mg/kg, PO) impaired avoidance and rotarod performance, and caused bradycardia and hypothermia. Phencyclidine (PCP; 1.25, 2.5, 5.0 mg/kg, IP) impaired avoidance and rotarod performance and caused a marked increase in photocell activity. When combined, the depressant properties of each drug were enhanced and the stimulation of photocell activity cg/kg THC and its interactions with PCP followed subacute treatment for six days, whereas many of the effects of PCP were enhanced after subacute treatment with a dose of 2.5 mg/kg. Open-field behavior was affected by each drug alone and in combination in a similar way as photocell activity, but the depression caused by their interaction was greater; both drugs caused an increase in urination. Response rates on an FR-10 schedule of food reinforcement were decreased by 2.5 mg/kg PCP, but not by 5.0 mg/kg THC; the combination caused greater response suppression than either drug alone. The functional interactions between THC and PCP were not related to changes in the concentrations of 14C or 3H in plasma or brain derived from 14C-delta9-THC and 3H-PCP, respectively.
9-四氢大麻酚（THC；2.5、5.0、10.0毫克/千克，口服）损害了回避和转棒实验表现，并导致心动过缓和体温过低。苯环己哌啶（PCP；1.25、2.5、5.0毫克/千克，腹腔注射）损害了回避和转棒实验表现，并导致光电管活动显著增加。联合使用时，每种药物的抑制特性增强，且在亚急性治疗六天后，2.5毫克/千克THC及其与PCP的相互作用对光电管活动产生刺激，而用2.5毫克/千克剂量进行亚急性治疗后，PCP的许多效应增强。旷场行为受到每种药物单独作用及联合作用的影响，方式与光电管活动相似，但它们相互作用引起的抑制作用更大；两种药物均导致排尿增加。在固定比率为10的食物强化实验中，2.5毫克/千克PCP降低了反应率，但5.0毫克/千克THC未产生此效果；联合使用比单独使用任何一种药物导致的反应抑制作用更强。THC与PCP之间的功能相互作用与分别源自14C-9-THC和3H-PCP的血浆或大脑中14C或3H浓度的变化无关。
