单次口服剂量后人体血清、精浆和唾液中的普萘洛尔浓度。
Propranolol concentrations in blood serum, seminal plasma and saliva in man after a single oral dose.
作者信息
Mahajan P, Grech E D, Pearson R M, Ridgway E J, Turner P
出版信息
Br J Clin Pharmacol. 1984 Dec;18(6):849-52. doi: 10.1111/j.1365-2125.1984.tb02554.x.
Abstract
A single dose of 80 mg racemic propranolol hydrochloride was administered by mouth to six healthy male volunteers. The mean concentration achieved in seminal plasma at 2 h after dosing was almost identical to that in blood serum. The concentrations of propranolol in seminal plasma and saliva were much less than those known to reduce sperm motility by 50% in vitro. The concentrations in saliva did not reflect those in blood serum. Propranolol in the dose administered in this study is unlikely to affect fertility by its presence in saliva or semen.
摘要
对6名健康男性志愿者口服单剂量80毫克消旋盐酸普萘洛尔。给药后2小时精浆中达到的平均浓度与血清中的几乎相同。精浆和唾液中普萘洛尔的浓度远低于已知在体外使精子活力降低50%的浓度。唾液中的浓度不能反映血清中的浓度。本研究中给予剂量的普萘洛尔不太可能因其在唾液或精液中的存在而影响生育能力。
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