普萘洛尔作为一种新型有效杀精剂的初步研究结果。
Propranolol as a novel, effective spermicide: preliminary findings.
作者信息
Zipper J, Wheeler R G, Potts D M, Rivera M
出版信息
Br Med J (Clin Res Ed). 1983 Oct 29;287(6401):1245-6. doi: 10.1136/bmj.287.6401.1245.
Abstract
The efficacy and tolerability of 80 mg propranolol tablets as a vaginal contraceptive were studied in 198 fertile women for 11 months. The calculated one year life table pregnancy rate was 3.4/100 women and the Pearl index was 3.9/100 women years. No major adverse effects were encountered. The findings suggested that propranolol is an effective vaginal contraceptive whose failure rate compares favourably with that of other methods of contraception. Further study of propranolol and similar compounds is warranted.
摘要
对198名育龄妇女进行了为期11个月的研究，以探讨80毫克普萘洛尔片作为阴道避孕药的有效性和耐受性。计算得出的一年生命表妊娠率为3.4/100名妇女，Pearl指数为3.9/100妇女年。未发现重大不良反应。研究结果表明，普萘洛尔是一种有效的阴道避孕药，其失败率与其他避孕方法相比具有优势。有必要对普萘洛尔及类似化合物进行进一步研究。
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