Trotta F, Biagini G, Cenacchi G, Ballardini G, Varotti C, Passarini B, Garbisa S, Faccani G, Bianchi F B, Govoni E
Clin Exp Rheumatol. 1984 Jul-Sep;2(3):209-15.
Fifteen patients affected by Progressive Systemic Sclerosis have been studied. With immunofluorescence, specific antibodies against collagen type IV and laminin clearly outlined the microvessels, while endothelial cells showed a brilliant heavy fluorescence for vimentin antibodies. In the deep dermis, fibronectin proved to have increased. At electron microscopy, microvessels appeared with occluded lumina due to the presence of swollen endothelial cells. Endothelial cytoplasm was filled with intermediate filaments (vimentin type), generally condensed into peripherally located bundles or in perinuclear rings. The perivascular basal lamina was thickened and laminated. Although these changes do not demonstrate a specific pattern, representing a common step in several connective tissue disorders, the data tend to confirm a clear involvement of the microvasculature in Progressive Systemic Sclerosis.
对15例进行性系统性硬化症患者进行了研究。通过免疫荧光法，抗IV型胶原和层粘连蛋白的特异性抗体清晰勾勒出微血管，而内皮细胞对波形蛋白抗体呈现明亮的强荧光。在真皮深层，纤连蛋白含量增加。电子显微镜下，由于内皮细胞肿胀，微血管管腔闭塞。内皮细胞质充满中间丝（波形蛋白型），通常聚集成周边束状或核周环状。血管周围基膜增厚并呈层状。尽管这些变化未显示出特定模式，而是几种结缔组织疾病的共同特征，但数据倾向于证实微血管在进行性系统性硬化症中明显受累。
