Krajnc I, Vizjak A, Hvala A, Jurcic V, Rozman B
Abteilung für Rheumatologie, Lehrkrankenhauses Maribor, Slowenien.
Acta Med Austriaca. 1998;25(3):109-12.
Scleromyxedema (SM) may be considered as a possible disease entity in the differential diagnosis of scleroderma. Clinical data and the results of light, immunohistochemical, immunofluorescence and electron microscopic study of skin biopsies taken from a 53-year old patient with SM are reported. In the patient with SM in which abnormal serum paraprotein was not identified, the skin biopsy showed mucinous material in the dermis and proliferation of fibroblasts accompanied by mild dermal sclerosis. Immunofluorescence showed scanty granular IgG along the epidermal basement membrane and IgG and C1q focally along the connective tissue fibres in the dermis of clinically involved skin. In addition to clinical findings, detailed skin biopsy studies including contemporary techniques can contribute to the diagnosis of the disease.
硬化性黏液水肿（SM）在硬皮病的鉴别诊断中可被视为一种可能的疾病实体。本文报告了一名53岁SM患者皮肤活检的临床数据以及光镜、免疫组化、免疫荧光和电镜研究结果。在未发现异常血清副蛋白的SM患者中，皮肤活检显示真皮中有黏液物质和成纤维细胞增殖，并伴有轻度真皮硬化。免疫荧光显示，在临床受累皮肤的真皮中，沿表皮基底膜有少量颗粒状IgG，沿结缔组织纤维有IgG和C1q局灶性沉积。除临床发现外，包括现代技术在内的详细皮肤活检研究有助于该疾病的诊断。
