Osaki Y, Koga S, Maeta M, Shimizu N, Kanayama H, Hamazoe R
Jpn J Surg. 1984 Nov;14(6):524-6. doi: 10.1007/BF02469797.
Immune complexes (IC) were measured in 66 gastric cancer patients, using the 3.5 percent polyethylene glycol (PEG) precipitation method. Preoperatively, the IC values in patients with advanced gastric cancer (stages III and IV) were significantly higher than in normal subjects (p less than 0.01). In the presence of 3.5 percent PEG-precipitated IC from sera of gastric cancer patients, the mitogen responses of normal peripheral blood lymphocytes was inhibited; the PHA response revealed a significant negative correlation with the concentration of IC (p less than 0.01). Our data suggest that IC may be a major serum factor exerting immunosuppressive effect in cancer hosts.
采用3.5%聚乙二醇（PEG）沉淀法对66例胃癌患者进行免疫复合物（IC）检测。术前，进展期胃癌（Ⅲ期和Ⅳ期）患者的IC值显著高于正常受试者（p<0.01）。在含有3.5%PEG沉淀的胃癌患者血清IC的情况下，正常外周血淋巴细胞的丝裂原反应受到抑制；PHA反应与IC浓度呈显著负相关（p<0.01）。我们的数据表明，IC可能是癌症宿主中发挥免疫抑制作用的主要血清因子。
